PMID- 26500463 OWN - NLM STAT- MEDLINE DCOM- 20160329 LR - 20201209 IS - 1550-2783 (Print) IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 12 DP - 2015 TI - Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects. PG - 40 LID - 10.1186/s12970-015-0101-z [doi] LID - 40 AB - BACKGROUND: Zeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance. METHODS: In a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20-50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO2max and maximum performance were evaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used. RESULTS: At baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group. There were no significant changes observed in the other measured parameters. CONCLUSIONS: Twelve weeks of zeolite supplementation exerted beneficial effects on intestinal wall integrity as indicated via decreased concentrations of the tight junction modulator zonulin. This was accompanied by mild anti-inflammatory effects in this cohort of aerobically trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study. FAU - Lamprecht, Manfred AU - Lamprecht M AD - Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ; Institute of Nutrient Research and Sport Nutrition, Graz, Austria. FAU - Bogner, Simon AU - Bogner S AD - Institute of Nutrient Research and Sport Nutrition, Graz, Austria. FAU - Steinbauer, Kurt AU - Steinbauer K AD - SportchirurgiePlus, Graz, Austria. FAU - Schuetz, Burkhard AU - Schuetz B AD - Biovis Diagnostic MVZ GmbH, Limburg, Germany. FAU - Greilberger, Joachim F AU - Greilberger JF AD - Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ; Institute of Laboratory Sciences, Dr Greilberger GmbH, Laßnitzhöhe, Austria. FAU - Leber, Bettina AU - Leber B AD - Department of Surgery, Division of Transplantation Surgery, Medical University of Graz, Graz, Austria. FAU - Wagner, Bernhard AU - Wagner B AD - FH JOANNEUM Ltd, Graz, Austria. FAU - Zinser, Erwin AU - Zinser E AD - FH JOANNEUM Ltd, Graz, Austria. FAU - Petek, Thomas AU - Petek T AD - Medical and Chemical Laboratory diagnostics Lorenz & Petek Ltd, Graz, Austria. FAU - Wallner-Liebmann, Sandra AU - Wallner-Liebmann S AD - Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria. FAU - Oberwinkler, Tanja AU - Oberwinkler T AD - Panaceo International Active Mineral Production GmbH, Villach, Austria. FAU - Bachl, Norbert AU - Bachl N AD - Institute of Sport Science, University of Vienna, Vienna, Austria. FAU - Schippinger, Gert AU - Schippinger G AD - SportchirurgiePlus, Graz, Austria. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20151020 TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 RN - 0 (Biomarkers) RN - 0 (Haptoglobins) RN - 0 (Interleukin-6) RN - 0 (Interleukin-8) RN - 0 (Interleukins) RN - 0 (Protein Precursors) RN - 0 (Tumor Necrosis Factor-alpha) RN - 0 (zonulin) RN - 130068-27-8 (Interleukin-10) RN - 1318-02-1 (Zeolites) RN - 9012-63-9 (Cholera Toxin) RN - XEO71E2E45 (interleukin-22) SB - IM MH - Adult MH - Biomarkers/blood MH - Cholera Toxin/metabolism MH - DNA Damage MH - *Dietary Supplements MH - Double-Blind Method MH - Feces/chemistry MH - Female MH - Haptoglobins MH - Humans MH - Inflammation/blood/*drug therapy MH - Interleukin-10/blood MH - Interleukin-6/blood MH - Interleukin-8/blood MH - Interleukins/blood MH - Intestines/*drug effects MH - Male MH - Middle Aged MH - Nutrition Assessment MH - Oxygen Consumption MH - Permeability MH - Protein Precursors MH - Tight Junctions/drug effects MH - Tumor Necrosis Factor-alpha/blood MH - Zeolites/*pharmacology PMC - PMC4617723 OTO - NOTNLM OT - Leaky gut OT - Tight junctions OT - Trained subjects OT - Zeolite supplementation OT - Zonulin EDAT- 2015/10/27 06:00 MHDA- 2016/03/30 06:00 CRDT- 2015/10/27 06:00 PHST- 2015/03/09 00:00 [received] PHST- 2015/10/13 00:00 [accepted] PHST- 2015/10/27 06:00 [entrez] PHST- 2015/10/27 06:00 [pubmed] PHST- 2016/03/30 06:00 [medline] AID - 101 [pii] AID - 10.1186/s12970-015-0101-z [doi] PST - epublish SO - J Int Soc Sports Nutr. 2015 Oct 20;12:40. doi: 10.1186/s12970-015-0101-z. eCollection 2015.